| Competitie | vr 03/09/2021 | 20:00 | Cappellen FC – Nijlen | 4-0 |
| Competitie | vr 10/09/2021 | 20:00 | Houtvenne – Cappellen FC | 2-2 |
| Competitie | vr 17/09/2021 | 20:30 | Cappellen FC – Berlaar Heikant | 5-1 |
| Competitie | vr 24/09/2021 | 20:00 | RC Mechelen – Cappellen FC | 1-1 |
| Competitie | vr 01/10/2021 | 20:00 | Cappellen FC – Londerzeel | 3-1 |
| Competitie | za 09/10/2021 | 14:00 | Diest – Cappellen FC | 0-9 |
| Competitie | vr 15/10/2021 | 20:30 | Betekom – Cappellen FC | 1-1 |
| Competitie | vr 29/10/2021 | 20:00 | Lyra-Lierse – Cappellen FC | 1-4 |
| Competitie | vr 05/11/2021 | 20:30 | Cappellen FC – City Pirates | 5-1 |
| Competitie | vr 12/11/2021 | 20:30 | Overijse – Cappellen FC | 3-3 |
| Competitie | vr 19/11/2021 | 20:30 | Cappellen FC – Wijgmaal | 0-2 |
| Competitie | vr 26/11/2021 | 20:15 | Eppegem – Cappellen FC | 3-2 |
| Competitie | vr 03/12/2021 | 20:30 | Cappellen FC – Diegem Sport | 0-2 |
| Competitie | vr 10/12/2021 | 20:00 | Berchem Sport – Cappellen FC | 1-2 |
| Competitie | vr 17/12/2021 | 20:00 | Nijlen – Cappellen FC | 3-2 |
| Competitie | vr 14/01/2022 | 20:00 | Cappellen FC – Houtvenne | 3-0 |
| Competitie | vr 21/01/2022 | 20:30 | Berlaar Heikant – Cappellen FC | 0-4 |
| Competitie | vr 28/01/2022 | 20:00 | Cappellen FC – RC Mechelen | 3-1 |
| Competitie | vr 04/02/2022 | 20:30 | Londerzeel – Cappellen FC | 5-2 |
| Competitie | ma 14/02/2022 | 20:00 | Cappellen FC – Diest | 4-1 |
| Competitie | vr 18/02/2022 | 20:00 | Cappellen FC – Betekom | uitgesteld |
| Competitie | vr 11/03/2022 | 20:00 | Cappellen FC – Lyra Lierse | 2-7 |
| Competitie | vr 18/03/2022 | 20:00 | City Pirates – Cappellen FC | 1-2 |
| Competitie | vr 25/03/2022 | 20:00 | Cappellen FC – Overijse | 2-2 |
| Competitie | vr 01/04/2022 | 20:30 | Wijgmaal – Cappellen FC | 3-1 |
| Competitie | vr 08/04/2022 | 20:00 | Cappellen FC – Eppegem | 5-0 forfait |
| Competitie | vr 22/04/2022 | 20:15 | Diegem Sport – Cappellen FC | 3-0 |
| Competitie | vr 29/04/2022 | 20:00 | Cappellen FC – Berchem Sport | 1-2 |